Simotinib hydrochloride is a selective, specific, and orally bioavailableEGFRtyrosine kinase inhibitor, with anIC₅₀of 19.9 nM. Antineoplastic activities^[1].

Simotinib hydrochloride inhibits in a dose-dependent manner EGFR and the growth of human A431 tumor cells with high expression of EGFR, with no significant activity on other investigated kinases^[1].

Simotinib hydrochloride has been shown to exert its antitumor activity by inhibiting EGFR phosphorylation in nude xenograft model^[1].

537.41

C₂₅H₂₇Cl₂FN₄O₄

1538617-88-7

Room temperature in continental US; may vary elsewhere.

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