Tyrphostin 8 is atyrosine kinase, with anIC₅₀of 560 μM forEGFRkinase. Tyrphostin 8 is also aGTPaseinhibitor. Tyrphostin 8 can inhibit the proteinserine/threonine phosphatasecalcineurin(IC₅₀=21 μM)^[1][2][3].

Tyrphostin 8 (10-100 μM; pretreated for 20 min) blocks the Carbachol-initiated PKCδ tyrosine phosphorylation and ERK1/2 activation in parotid acinar cells^[1].
Tyrphostin 8 (10-100 μM) produces a rapid and large increase in the basal O₂consumption of parotid acinar^[1].
Tyrphostin 8 (10-100 μM) reduces the parotid ATP content by ~90% at the concentration of 100 μM^[1].
Tyrphostin 8 increases apical-to-basolateral transport of insulin-transferrin conjugate by enhancing transferrin receptor-mediated transcytosis in filter-grown Caco-2 cell monolayer^[2].

Tyrphostin 8 improves the glucose-lowering effect of Insulin-transferrin in Streptozotocin-induced diabetic rats^[2].

170.17

C₁₀H₆N₂O

3785-90-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.