PDE5-IN-3

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PDE5-IN-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2538149-57-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PDE5-IN-3 (compound 11j) 是一种有效的PDE5抑制剂，IC₅₀为 1.57 nM。PDE5-IN-3 对EGFR显示中度抑制作用，IC₅₀为 5.827 μM。PDE5-IN-3 显着抑制 Wnt/β-catenin 通路 (IC₅₀=1286.96 ng/mL)。PDE5-IN-3 在 HepG2 细胞中诱导内在的凋亡线粒体途径。PDE5-IN-3 具有很强的抗肿瘤活性。

生物活性

PDE5-IN-3 (compound 11j) is a potentPDE5inhibitor with anIC₅₀of 1.57 nM. PDE5-IN-3 shows moderateEGFRinhibition with IC₅₀of 5.827 μM. PDE5-IN-3 significantly inhibits the Wnt/β-catenin pathway (IC₅₀=1286.96 ng/mL). PDE5-IN-3 induces the intrinsicapoptoticmitochondrial pathway in HepG2 cells. PDE5-IN-3 has strong antitumor activity^[1].

IC₅₀& Target^[1]

PDE5

1.57 nM (IC₅₀)

EGFR

5.827 μM (IC₅₀)

体外研究
(In Vitro)

PDE5-IN-3 lowers the expression levels of the anti-apoptotic Bcl-2 protein, and causes the high expression of the pro-apoptotic protein Bax, p53, cytochrome c and up-regulates active caspase-9 and caspase-3 levels^[1].

分子量

448.27

Formula

C₂₁H₁₄BrN₅O₂

CAS 号

2538149-57-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.