Sacibertinib

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Sacibertinib

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1351941-69-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Sacibertinib 是一种酪氨酸激酶 (Trk)抑制剂，对EGFR-TK磷酸化和HER2的EC₅₀分别为 110 nM 和 244 nM。具有抗肿瘤活性。

生物活性

Sacibertinib is atyrosine kinase (Trk)inhibitor withEC₅₀value of 110 nM and 244 nM forEGFR-TKphosphorylation andHER2, respectively. Antineoplastic activity^[1].

IC₅₀& Target^[1]

EGFR-TK phosphorylation

110 nM (EC₅₀)

HER2

244 nM (EC₅₀)

体外研究
(In Vitro)

Sacibertinib has inhibitory activity against Sk-Br-3, SW620 cells with GI₅₀s of 3.8 nM and 1.78 μM, and against CCRF-CEM/T, Fadu, BxPc-3 and AsPC-1 with IC₅₀s of 5.6 μM, 101 nM, 337 nM and 1 μM, respectively^[1].

分子量

599.08

Formula

C₃₂H₃₁ClN₆O₄

CAS 号

1351941-69-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.