CAS NO: | 2227455-78-7 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | EGFR-IN-1 hydrochloride is an orally active and irreversibleL858R/T790M mutant selectiveEGFRinhibitor. EGFR-IN-1 hydrochloride potently inhibits Gefitinib-resistantEGFRL858R, T790M with 100-fold selectivity over wild-typeEGFR. EGFR-IN-1 hydrochloride displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity[1]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | EGFR-IN-1 hydrochloride (compound 24) (10 μM; 72 hours) displays strong antiproliferative activity against the H1975 and HCC827 cells with IC50s of 4 and 28 nM, respectively[1]. Cell Proliferation Assay[1]
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体内研究 (In Vivo) | EGFR-IN-1 hydrochloride (30 mg/kg; p.o.; daily for 2 weeks) displays significant tumor growth inhibition with no observed loss in body weight[1].
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分子量 | 551.04 | ||||||||
Formula | C28H31ClN6O4 | ||||||||
CAS 号 | 2227455-78-7 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |