Fexofenadine

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Fexofenadine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

83799-24-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

MDL-16455
Terfenadine carboxylate

产品介绍

Fexofenadine (MDL-16455) 是一种具有口服活性和非镇静性的H₁受体拮抗剂。Fexofenadine 可用于过敏性鼻炎和慢性特发性荨麻疹的研究。

生物活性

Fexofenadine (MDL-16455) is an orally active and nonsedativeH1 receptorantagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research^[1]^[2]^[3].

IC₅₀& Target^[1]

H₁Receptor

体外研究
(In Vitro)

Fexofenadine (1-100 μM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner^[2].
Fexofenadine (1-100 μM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK^[2].

Western Blot Analysis^[2]

Cell Line:	Nasal fibroblasts
Concentration:	100 μM
Incubation Time:	1 hour
Result:	Blocked pp38 activation in histamine-induced nasal fibroblasts, showed histamine-induced IL-6 production mediated by the p38 pathway.

体内研究
(In Vivo)

Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected withT. spiralis^[1].

Animal Model:	C57BL/6 mice infected withTrichinella spiralis^[1]
Dosage:	5, 10 and 20 mg/kg
Administration:	Oral administration; 5, 10 and 20 mg/kg; once daily; 3 weeks
Result:	Inhibited eosinophilia in a dose-dependent manner. Suppressed the decrease in rectal temperature (p<0.01), a marker for systemic anaphylaxis.

Clinical Trial

分子量

501.66

Formula

C₃₂H₃₉NO₄

CAS 号

83799-24-0

中文名称

非索芬那定

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.