CAS NO: | 77326-96-6 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Flunisolide hemihydrate is a corticosteroid, which is an orally activeglucocorticoid receptoractivator withanti-inflammatoryactivity. Flunisolide hemihydrate can induce eosinophilapoptosis, and is used for the research of asthma or rhinitis, and inflammation[1][2]. | ||||||||
体外研究 (In Vitro) | Flunisolide hemihydrate (0.1-10 μM, 1 h) inhibits lung fibroblast (Isolated from lung) activation[1].Flunisolide hemihydrate (10 μM, 24 h) reduces MMP-9, TIMP-1, TGF-β and fibronectin release by sputum cells (isolated from mild to moderate asthmatics), and induces sputum eosinophil apoptosis[2].Flunisolide hemihydrate (0.1-10 μM μM, 24 h) effectively inhibits ICAM-1 expression and GM-CSF and IL-5 release induced by TNF-alpha in BEAS-2B cells[3].Flunisolide hemihydrate (115 μM, 0-3 h) can be transported in a polarized way in the apical (ap) to basolateral (bl) direction in Calu-3 cells and is demonstrated to be ATP-dependent[4]. Apoptosis Analysis[2]
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体内研究 (In Vivo) | Flunisolide hemihydrate (Intranasal administration, 0.3-10 μg/mouse, daily, from days 21–27) inhibits lung inflammation, fibrosis, and airway hyper-reactivity, also improves clearance of silica particles from the lungs in silicotic mice[1].Flunisolide hemihydrate (Intranasal administration, 0.3-10 μg/mouse, daily, from days 21–27) inhibits silica-induced macrophage and myofibroblast accumulation in the lung tissue[1].
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Clinical Trial | |||||||||
分子量 | 443.51 | ||||||||
Formula | C24H33FO7 | ||||||||
CAS 号 | 77326-96-6 | ||||||||
中文名称 | 氟尼缩松半水合物 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |