Glucocorticoid receptor-IN-1 (Compound WX002) is a selectiveglucocorticoid receptor(GR)modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with anIC₅₀of 2.11 nM againsthMMP1, and transcriptional activation activity with anEC₅₀of 5.59 nM againstMMTV^[1].

Glucocorticoid receptor-IN-1 (Compound WX002) shows inhibitory effect on CYP3A4 with an IC₅₀of 16.7 μM^[1].

513.45

C₂₄H₁₉F₄N₇O₂

2662908-25-8

Room temperature in continental US; may vary elsewhere.

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