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Timegadine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Timegadine图片
CAS NO:71079-19-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
替美加定
SR1368
产品介绍
Timegadine 是一种新的抗炎药,被发现是一种有效的竞争性前列腺素合成酶抑制剂,同时也能抑制环加氧酶和脂氧合酶。
生物活性

Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor ofcyclo-oxygenase(COX) andlipo-oxygenase, withIC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) forCOXand 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets.

IC50& Target

COX

5 nM (IC50, in rabbit platelets)

COX

20 μM (IC50, in rat brain)

lipo-oxygenase

100 μM (IC50, in horse and washed rabbit platelets)

体外研究
(In Vitro)

Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets[2].

体内研究
(In Vivo)

Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of prostaglandin synthetase which also inhibits cyclo-oxygenase (COX) and lipoxygenase. Daily oral doses of 10 to 30 mg/kg of Timegadine significantly inhibit both the primary and secondary lesions of adjuvant arthritis when the treatment is initiated on the day of the disease induction and continues for 28 days. Timegadine is able specifically to prevent the development of the swelling of the non-injected paw until 28 days after the adjuvant injection when administered for 5 days prior to and 5 days after the induction of the disease, in analogy with the effect of cyclophosphamide[1].

分子量

365.50

Formula

C20H23N5S

CAS 号

71079-19-1

中文名称

替美加定

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.