CAS NO: | 71079-19-1 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor ofcyclo-oxygenase(COX) andlipo-oxygenase, withIC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) forCOXand 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets. | |||
IC50& Target |
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体外研究 (In Vitro) | Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets[2]. | |||
体内研究 (In Vivo) | Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of prostaglandin synthetase which also inhibits cyclo-oxygenase (COX) and lipoxygenase. Daily oral doses of 10 to 30 mg/kg of Timegadine significantly inhibit both the primary and secondary lesions of adjuvant arthritis when the treatment is initiated on the day of the disease induction and continues for 28 days. Timegadine is able specifically to prevent the development of the swelling of the non-injected paw until 28 days after the adjuvant injection when administered for 5 days prior to and 5 days after the induction of the disease, in analogy with the effect of cyclophosphamide[1]. | |||
分子量 | 365.50 | |||
Formula | C20H23N5S | |||
CAS 号 | 71079-19-1 | |||
中文名称 | 替美加定 | |||
运输条件 | Room temperature in continental US; may vary elsewhere. | |||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |