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COX-2/PI3K-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
COX-2/PI3K-IN-1图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
COX-2/PI3K-IN-1 (compound 5d) 是一种有效的PI3K抑制剂,IC50值为 1.14 nM。COX-2/PI3K-IN-1 是一种选择性COX-2抑制剂,Ki值为 3.24 nM。COX-2/PI3K-IN-1 具有抗炎和抗癌特性。
生物活性

COX-2/PI3K-IN-1 (compound 5d) is a potentPI3Kinhibitor withIC50value of 1.14 nM. COX-2/PI3K-IN-1 is a selectiveCOX-2inhibitor withKivalue of 3.24 nM. COX-2/PI3K-IN-1 has anti-inflammatory and anti-cancer properties.

IC50& Target[1]

PI3K

1.14 nM (IC50)

COX-2

3.24 nM (Ki)

体外研究
(In Vitro)

COX-2/PI3K-IN-1 (compound 5d) (50-500 μg/mL, 72 hours) exerts potent antitumor activities against Breast cancer (MCF-7) cells[1].
COX-2/PI3K-IN-1 (compound 5d) (10-150 μg/mL) has antioxidant properties with H2O2scavenging activity equivalent to ascorbic acid and higher lysozyme inhibition(IC50=3.98 nM)[1].

Cell Cytotoxicity Assay[1]

Cell Line:Breast cancer (MCF-7) cells and normal breast epithelial (MCF-10A) cells
Concentration:50–500 μg/mL
Incubation Time:72 hours
Result:Caused 40 % cell death at 0.75 μM in MCF-7 cells.
分子量

411.93

Formula

C19H14ClN5S2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.