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Ketoprofen(lysinate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ketoprofen(lysinate)图片
CAS NO:57469-78-0
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
RP-19583 (lysinate)
产品介绍
Ketoprofen (RP-19583) lysinate 是一种非甾体抗炎剂，可抑制 cyclooxygenase 的活性，其IC50值为 2 nM (COX-1) 和 26 nM (COX-2)。Ketoprofen lysinate 可用于炎症、免疫学和代谢性疾病 (如肥胖) 的相关研究。
生物活性

Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase withIC50values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, andmetabolic diseasesuch as obesity[1][2][3].

IC50& Target

COX-1

2 nM (IC50)

COX-2

26 nM (IC50)

体外研究
(In Vitro)

Ketoprofen lysinate inhibits COX in LPS-stimulated monocytes isolated from human blood, with IC50values of 2 nM (COX-1) and 26 nM (COX-2)[1].
Ketoprofen lysinate (2.5 mg /mL, 3-24h) decreases the mRNA level of immune factors (TNFα, IL-8, SAA and COX-2) and PTGES in LPS-stimulated bovine mammary epithelial cells[3].

RT-PCR[3]

Cell Line:LPS (0.2 μg/mL)-stimulated bovine mammary epithelial cells
Concentration:2.5 mg /mL
Incubation Time:3, 6, 24 h
Result:Decreased the mRNA level of TNFα, IL-8, SAA, COX-2 and PTGES.
体内研究
(In Vivo)

Ketoprofen lysinate (Oral administration, 10 mg/kg, three times a week for 10 weeks, HFD-induced obese C57BL/6 mice) decreases in relative body weight (15.41%), the iWAT mass (approximately 41%), and leptin (58.68%) and resistin (12.88%)[2].
Ketoprofen lysinate (50 mg/kg, LPS-treated dairy cows) lowers the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk induced by LPS[3].

Animal Model:HFD-induced obese C57BL/6 mice[2]
Dosage:10 mg/kg
Administration:Oral administration, three times a week for 10 weeks
Result:Decreased in relative body weight, the iWAT mass, and the level of leptin and resistin.
Animal Model:LPS (0.2 μg/mL)-treated dairy cows[3]
Dosage:50 mg/kg
Administration:Injection (Milk samples were taken every 30 min until 6 and 9 h)
Result:Lowered the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk.
Clinical Trial
分子量

400.47

Formula

C22H28N2O5

CAS 号

57469-78-0

中文名称

赖氨酸酮基布洛芬

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.