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Atazanavir sulfate(BMS-232632-05)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Atazanavir sulfate(BMS-232632-05)图片
CAS NO:229975-97-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Atazanavir (BMS-232632) 硫酸盐是一种高度选择性的 HIV-1 蛋白酶抑制剂,是第一个获批用于每日一次给药的蛋白酶抑制剂。
Cas No.229975-97-7
别名硫酸阿扎那韦; BMS-232632 sulfate
化学名methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate;sulfuric acid
Canonical SMILESCC(C)(C)C(C(=O)NC(CC1=CC=CC=C1)C(CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)C(C(C)(C)C)NC(=O)OC)O)NC(=O)OC.OS(=O)(=O)O
分子式C38H52N6O7.H2SO4
分子量802.9
溶解度≥ 28.7 mg/mL in DMSO with gentle warming, ≥ 4.05 mg/mL in EtOH with ultrasonic and warming
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Atazanavir sulfate (BMS-232632-05) is the sulfate salt form of atazanavir, a potent protease inhibitor (IP) for the treatment of human immunodeficiency virus 1 (HIV-1) infection, which prevents the formation of mature HIV virions through the selective inhibition of the virus-specific processing of viral gag and gag-pol polyproteins in infected cells. Although it shows strong anti-HIV-1 activity with MIC50ranging from 2 to 5 nM, atazanavir has lower antiviral activity against HIV-2 isolates. Atazanavir, which is metabolized by the hepatic cytochrome P450 (CYP) system resulting in two main inactive metabolites, is also an inhibitor of CYP3A4 isoenzyme and P-glycoprotein ATP-dependent efflux pump.

Reference

[1].Robin Wood. Atazanavir: its role in HIV treatment. Expert Rev Snti Infect Ther 2008; 6(6): 785-796