α-Chaconine inhibits the expressions ofCOX-2,IL-1β,IL-6, andTNF-αat the transcriptional level. α-Chaconine inhibits the LPS-induced expressions ofiNOSandCOX-2at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects^[1].

α-Chaconine attenuates the transcriptional activity of activator protein-1 (AP-1) by reducing the translocation and phosphorylation of c-Jun.α-Chaconine suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock.α-Chaconine also suppresses the phosphorylation of TGF-β-activated kinase-1 (TAK1), which lies upstream of MKK7/JNK signaling^[1].

852.06

Solid

C₄₅H₇₃NO₁₄

20562-03-2

阿尔法卡茄碱

• Alkaloids
• Pyrrole Alkaloids

• Alkaloids
• Piperidine Alkaloids

• Plants
• Gramineae
• Zea maysL.

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)