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Rutaecarpine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rutaecarpine图片
CAS NO:84-26-4
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
吴茱萸次碱
Rutecarpine
产品介绍
Rutaecarpine, 是吴茱萸中的生物碱,是COX-2的抑制剂,其IC50值为0.28 μM。
生物活性

Rutaecarpine, an alkaloid ofEvodia rutaecarpa, is an inhibitor ofCOX-2with anIC50value of 0.28 μM.

IC50& Target[1]

COX-2

0.28 μM (IC50, in BMMC)

COX-1

8.7 μM (IC50, in BMMC)

体外研究
(In Vitro)

Rutaecarpine has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems[2]. Rutaecarpine inhibits COX-2 and COX-1 dependent phases of PGD2 generation in BMMC in a concentration-dependent manner with an IC50of 0.28 μM and 8.7 μM, respectively. It inhibits COX-2-dependent conversion of exogenous arachidonic acid to PGE2in a dose-dependent manner by the COX-2-transfected HEK293 cells[1].

体内研究
(In Vivo)

Rutaecarpine showedin vivoanti-inflammatory activity on rat l-carrageenan induced paw edema by intraperitoneal administration[1]. Rutaecarpine significantly decreases the number of antibody-forming cells and causes weight decrease in spleen in a dose-dependent manner. In addition, rutaecarpine administered mice exhibit reduced splenic cellularity, decreased numbers of total T cells, CD4+ cells, CD8+ cells, and B cells in spleen. IL-2, interferon and IL-10 mRNA expressions are suppressed significantly by rutaecarpine treatment. The number of CD4+IL-2+ cells is reduced significantly following administration of mice with rutaecarpine[3].

分子量

287.32

性状

Solid

Formula

C18H13N3O

CAS 号

84-26-4

中文名称

吴茱萸次碱

结构分类
  • Alkaloids
  • Indole Alkaloids
来源
  • Plants
  • Rutaceae
  • Evodia rutaecarpa(Juss.) Benth.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL(174.02 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.4804 mL17.4022 mL34.8044 mL
5 mM0.6961 mL3.4804 mL6.9609 mL
10 mM0.3480 mL1.7402 mL3.4804 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。