Metyrosine

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Metyrosine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

672-87-7

包装与价格：

包装	价格(元)
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

Metyrosine 是一种选择性酪氨酸羟化酶 (tyrosine hydroxylase enzyme) 抑制剂。Metyrosine 具有抗炎和抗溃疡作用。Metyrosine 显著抑制高 COX-2 活性。Metyrosine 是一种非常有效的控制血压的药物。

生物活性

Metyrosine is a selectivetyrosine hydroxylase enzymeinhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits highCOX-2activity^[1]. Metyrosine is a very effective agent for blood pressure control^[2].

体外研究
(In Vitro)

Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines^[2].

体内研究
(In Vivo)

Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation^[1].
Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively^[1].

Animal Model:	Male albino Wistar rats (carrageenan-induced rat paw edema)^[2]
Dosage:	50, 100 or 200 mg/kg
Administration:	I.p.
Result:	Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h).

Clinical Trial

分子量

195.22

性状

Solid

Formula

C₁₀H₁₃NO₃

CAS 号

672-87-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 5 mg/mL(25.61 mM;ultrasonic and warming and adjust pH to 2 with HCl and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	5.1224 mL	25.6121 mL	51.2243 mL
5 mM	1.0245 mL	5.1224 mL	10.2449 mL
10 mM	0.5122 mL	2.5612 mL	5.1224 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。