Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of thecomplement systemC3with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates’complement system. Compstatin exhibits IC₅₀values of 63 μM and 12 μM for classical and alterative complement pathway, respectively^[1][2][3][4].

Compstatin exhibits an in vitro half-life in human blood of about2 hr^[2].
In solution, compstatin forms a β-turn at residues Gln-5–Gly-8 with the disulfide bridge Cys-2–Cys12, residues Ile-1–Val-4, and Thr-13, forming a hydrophobic cluster^[3].

Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures^[1].
Compstatin is stable in baboon plasma for more than 24 h^[1].
Pig xenografts survival is significantly longer in the Compstatin perfused group than in the control group^[2].

1550.77

Solid

C₆₆H₉₉N₂₃O₁₇S₂

206645-99-0

Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys12)

ICVVQDWGHHRCT-NH2 (Disulfide bridge: Cys2-Cys12)

坎普他汀

Room temperature in continental US; may vary elsewhere.

H₂O : 100 mg/mL(64.48 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 100 mg/mL (64.48 mM); Clear solution; Need ultrasonic