Ulimorelin (TZP-101) is aghrelin receptor (GRLN)agonist with anEC₅₀of 29 nM and aK_iof 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action atα1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition^[1][2][3].

Ulimorelin (TZP-101; 0.3-5 mg/kg; i.v.) causes a dose dependent increase in the numbers and amplitudes of phasic pressure waves recorded from the colorectum^[1].
Ulimorelin (1, 3, 5 mg/kg; i.v.) causes a substantial and prolonged (~1 h) increase in colorectal propulsive activity and expulsion of colonic contents^[1].
Ulimorelin (p.o.; 8 mg/kg) has a C_maxof 0.39 μM and a AUC of 82 μMomin for rats. Ulimorelin (i.v.; 2 mg/kg) has a T_1/2of 50 mins, a CL of 24 mL/min/kg, and a V_ssof 1.7 L/kg for rats^[3].

538.65

C₃₀H₃₉FN₄O₄

842131-33-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.