PEN (rat), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83^[1].

Mouse PEN (mPEN) and rat PEN (rPEN) only differ by one residue at the N-terminal end, whereas human PEN (hPEN) is more divergent and has the sequence PEG instead of PEN^[2].
PEN binds and activates a GPCR in the brain^[2].

2301.59

C₁₀₂H₁₆₉N₂₇O₃₃

569364-13-2

AVDQDLGPEVPPENVLGALLRV

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