Sarafotoxin S6a TFA

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Sarafotoxin S6a TFA

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Sarafotoxin S6a TFA 是一种 Sarafotoxin 类似物，是一种内皮素受体 (endothelin receptor) 激动剂，具有与 Endothelin-3 (HY-P0204) 相似的ET_A/ET_B选择性。Sarafotoxin S6a TFA 诱导猪冠状动脉的EC₅₀值为 7.5 nM。

生物活性

Sarafotoxin S6a TFA , a sarafotoxin analogue, is aendothelin receptoragonist and has anET_A/ET_Bselectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a TFA elicits the pig coronary artery with anEC₅₀ value of 7.5 nM^[1].

IC₅₀& Target^[1]

ET_B

ET_A

体外研究
(In Vitro)

Sarafotoxin S6a TFA is a rather weak agonist effect in guinea-pig aorta, the eliting concentration (EC₅₀) is 150 nM in guinea-pig aorta.

分子量

2628.87

Formula

C₁₀₇H₁₅₇F₃N₂₈O₃₆S₅

Sequence

Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridge:Cys1-Cys15;Cys3-Cys11)

Sequence Shortening

CSCKDMTDKECLNFCHQDVIW (Disulfide bridge:Cys1-Cys15;Cys3-Cys11)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vivo:

1.
S6a is dissolved in 0.1% aqueous acetic acid and diluted in 0.9% NaCl^[1].