CXCR4 antagonist 7

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CXCR4 antagonist 7

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1185451-72-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

CXCR4 antagonist 7 (Compound PARA-B) 是一种CXCR4拮抗剂，IC₅₀为 9.3 nM。CXCR4 antagonist 7 可用于 HIV 感染、炎症性疾病、癌症和 WHIM 综合征的研究。

生物活性

CXCR4 antagonist7 (Compound PARA-B) is aCXCR4antagonist with theIC₅₀of 9.3 nM.CXCR4 antagonist7 can be used for the research of HIVinfection, inflammatory diseases,cancer, and WHIM syndrome^[1].

IC₅₀& Target

CXCR4/CXCL12

9.3 nM (IC₅₀)

体外研究
(In Vitro)

CXCR4 antagonist 7 (PARA-B, 10 nM-1 μM, 20 h) inhibits CXCL12-induced GH4C1 cell proliferation with an IC₅₀value of 9.3 nM^[1].
CXCR4 antagonist 7 (1 μM, 12 h) inhibits CXCL12-dependent GH4C1 cell migration with inhibition rate of 50%^[1].
CXCR4 antagonist 7 (50 nM, 30 min) reduces ERK1/2 phosphorylation induced by CXCL12^[1].
CXCR4 antagonist 7 (50 nM-1 μM, 30 min) acts via CXCR4 antagonism to revert CXCL12 induction of GH4C1 proliferation and migration^[1].

Cell Viability Assay^[1]

Cell Line:	GH4C1 cell (48 h of serum deprivation)
Concentration:	1 μM
Incubation Time:	24 h
Result:	Had no effect on cell viability of GH4C1 cell.

Cell Proliferation Assay^[1]

Cell Line:	GH4C1 cell ( FBS-starved GH4C1 cells treated with CXCL12 (25 nM) for 12 h)
Concentration:	10 nM-1 μM
Incubation Time:	20 h, 24 h
Result:	Inhibited proliferation of multiple cancer cell lines with IC₅₀value ranging from 1.08 to 3.45 μM, and had no effect on cell viability of GH4C1cell.

Cell Migration Assay^[1]

Cell Line:	GH4C1 and GH4A11 cells (FBS-starved cells treated with CXCL12 (25 nM) for 48 h)
Concentration:	50 nM-1 μM
Incubation Time:	12 h for GH4C1, 30 min for GH4A11
Result:	Reduced the number of migrating GH4C1 cells significantly, had no effect on GH4A11 cell (CRISPR-CAS9, reduction in CXCR4 mRNA) migration.

Western Blot Analysis^[1]

Cell Line:	GH4C1 cell (FBS-starved cells treated with CXCL12 (25 nM) for 15 min)
Concentration:	50 nM
Incubation Time:	30 min
Result:	Reduced ERK1/2 phosphorylation induced by CXCL12.

分子量

315.33

Formula

C₁₅H₁₇N₅O₃

CAS 号

1185451-72-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.