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CTCE-0214
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:577782-52-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CTCE-0214 是一种CXCR4(chemokine CXC receptor 4) 激动剂,是 SDF-1α 肽类似物。CTCE-0214 具有抗炎活性,可用于炎症败血症和系统性炎症综合征的研究。
生物活性

CTCE-0214 is achemokine CXC receptor 4(CXCR4) agonist, SDF-1α (stromal cell-derived factor-1α) peptide analog. CTCE-0214 shows anti-inflammatory activity, and can be used in inflammation sepsis and systemic inflammatory syndromes research[1][2][3].

IC50& Target[1]

SDF-1α-CXCR4

 

体外研究
(In Vitro)

CTCE-0214 (0.01-0.1 ng/mL; 4 d) increases the expansion of CD34+ cells subsets[3].

体内研究
(In Vivo)

CTCE-0214 (intravenous injection; 1-25 mg/kg; once) treatment inhibits Lipopolysaccharide-induced plasma TNF-α production[1].
CTCE-0214 (intraperitoneal injection and intravenous injection; 25 mg/kg; once) decreases Zymosan-induced plasma TNF-α production[1].

Animal Model:Male CD-1 mice injected with Lipopolysaccharide[1]
Dosage:1, 10, or 25 mg/kg
Administration:Intravenous injection; 1, 10, or 25 mg/kg; once
Result:Decreased LPS-induced plasma TNF-α production in a dose dependent manor with a 93% reduction.
Showed no significant effect on LPS-induced plasma IL-6 and IL-10 production.
Animal Model:Zymosan-induced peritonitis mice model[1]
Dosage:25 mg/kg
Administration:Intraperitoneal injection and intravenous injection; 25 mg/kg; once
Result:Showed a significant reduction in plasma TNF-α (53 reduction, p<0.05).
CAS 号

577782-52-6

Sequence Shortening

KPVSLSYRAPFRFFGGGGLKWIQEYLEKALN-NH2 (Lactam:Lys20-Glu24)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.