CTCE-0214

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CTCE-0214

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

577782-52-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

CTCE-0214 是一种CXCR4(chemokine CXC receptor 4) 激动剂，是 SDF-1α 肽类似物。CTCE-0214 具有抗炎活性，可用于炎症败血症和系统性炎症综合征的研究。

生物活性

CTCE-0214 is achemokine CXC receptor 4(CXCR4) agonist, SDF-1α (stromal cell-derived factor-1α) peptide analog. CTCE-0214 shows anti-inflammatory activity, and can be used in inflammation sepsis and systemic inflammatory syndromes research^[1]^[2]^[3].

IC₅₀& Target^[1]

SDF-1α-CXCR4

体外研究
(In Vitro)

CTCE-0214 (0.01-0.1 ng/mL; 4 d) increases the expansion of CD34+ cells subsets^[3].

体内研究
(In Vivo)

CTCE-0214 (intravenous injection; 1-25 mg/kg; once) treatment inhibits Lipopolysaccharide-induced plasma TNF-α production^[1].
CTCE-0214 (intraperitoneal injection and intravenous injection; 25 mg/kg; once) decreases Zymosan-induced plasma TNF-α production^[1].

Animal Model:	Male CD-1 mice injected with Lipopolysaccharide^[1]
Dosage:	1, 10, or 25 mg/kg
Administration:	Intravenous injection; 1, 10, or 25 mg/kg; once
Result:	Decreased LPS-induced plasma TNF-α production in a dose dependent manor with a 93% reduction. Showed no significant effect on LPS-induced plasma IL-6 and IL-10 production.

Animal Model:	Zymosan-induced peritonitis mice model^[1]
Dosage:	25 mg/kg
Administration:	Intraperitoneal injection and intravenous injection; 25 mg/kg; once
Result:	Showed a significant reduction in plasma TNF-α (53 reduction, p<0.05).

CAS 号

577782-52-6

Sequence Shortening

KPVSLSYRAPFRFFGGGGLKWIQEYLEKALN-NH2 (Lactam:Lys20-Glu24)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.