CXCR2-IN-1

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CXCR2-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1873376-49-8

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

CXCR2-IN-1是可渗透中枢神经系统的CXCR2拮抗剂，pIC₅₀值为9.3。

生物活性

CXCR2-IN-1 is a central nervous system penetrantCXCR2antagonist with apIC₅₀of 9.3.

IC₅₀& Target^[1]

CXCR2

9.3 (pIC₅₀)

体外研究
(In Vitro)

CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 (compound 22) shows favorable central nervous system penetration property (Br/Bl>0.45)^[1].

体内研究
(In Vivo)

CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis^[1].

分子量

476.35

性状

Solid

Formula

C₁₉H₂₀Cl₂FN₃O₄S

CAS 号

1873376-49-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 5.4 mg/mL(11.34 mM;Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.0993 mL	10.4965 mL	20.9930 mL
5 mM	0.4199 mL	2.0993 mL	4.1986 mL
10 mM	0.2099 mL	1.0496 mL	2.0993 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。