SB-332235

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SB-332235

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

276702-15-9

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品介绍

SB-332235 是一种高效、口服活性、选择性的非肽CXCR2拮抗剂，IC₅₀为 7.7 nM。SB-332235 对 CXCR2 的选择性比 CXCR1 高 285 倍。SB-332235 对家兔急性和慢性关节炎模型的抑制作用。SB-332235 抑制 AML 细胞活性。

生物活性

SB-332235 is a potent, orally active nonpeptideCXCR2antagonist, with anIC₅₀of 7.7 nM. SB-332235 displays 285-fold selectivity forCXCR2overCXCR1. SB-332235 inhibits acute and chronic models of arthritis in the rabbit. SB-332235 inhibits viability of AML cells^[1]^[2].

体外研究
(In Vitro)

SB-332235 (1-100 μM; 48 hours) inhibits viability of AML cell lines^[2].

Cell Viability Assay^[2]

Cell Line:	AML cell
Concentration:	1, 10, 100 μM
Incubation Time:	48 hours
Result:	Led to a dose-dependent decrease in proliferation in all cell lines.

体内研究
(In Vivo)

SB-332235 (25 mg/kg, p.o., b.i.d.) exhibits significantly reduced numbers of total leukocytes in synovial fluids from IL-8-injected knees^[1].
SB-332235 (10-25 mg/kg; p.o.; twice a day for 14 days) inhibits chronic Ag-induced arthritis^[1].

Animal Model:	Adult female New Zealand White rabbits (chronic OVA-induced model of arthritis)^[1]
Dosage:	10, 25 mg/kg
Administration:	P.o.; twice a day for 14 days
Result:	Day-15 synovial fluid leukocyte numbers in OVA-injected knees were significantly reduced in rabbits. The decrease in neutrophils, monocytes, and lymphocytes resulting from treatment with 25 mg/kg of the antagonist was accompanied by a significant reduction in synovial fluid PGE2, LTB4, LTC4, and IL-8 levels.

分子量

410.66

Formula

C₁₃H₁₀Cl₃N₃O₄S

CAS 号

276702-15-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.