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Urocortin,rat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:171543-83-2
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议

产品名称
Urocortin (Rattus norvegicus)
Rat urocortin
产品介绍
Urocortin, rat (Urocortin (Rattus norvegicus)) 是一种神经肽,也是一种有效的内源性CRFR激动剂,对人CRF1,大鼠CRF和小鼠CRFKi分别为 13 nM,1.5 nM 和 0.97 nM。
生物活性

Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenousCRFRagonist withKis of 13 nM, 1.5 nM, and 0.97 nM forhuman CRF1,rat CRFandmouse CRF, respectively[1][2].

IC50& Target

Ki: 0.32 nM (hCRF1), 2.2 nM (rCRF2α), and 0.62 nM (mCRF2β)[1]

体外研究
(In Vitro)

Urocortin, rat induces cyclic AMP (cAMP) generation with EC50of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRFand mouse CRF, respectively in stably transfected Chinese hamster ovary cells[2].

体内研究
(In Vivo)

Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior[3].

分子量

4707.26

Formula

C206H338N62O64

CAS 号

171543-83-2

Sequence

Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

Sequence Shortening

DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.