Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenousCRFRagonist withK_is of 13 nM, 1.5 nM, and 0.97 nM forhuman CRF₁,rat CRF_2αandmouse CRF_2β, respectively^[1][2].

Ki: 0.32 nM (hCRF1), 2.2 nM (rCRF2α), and 0.62 nM (mCRF2β)^[1]

Urocortin, rat induces cyclic AMP (cAMP) generation with EC₅₀of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF₁, rat CRF_2αand mouse CRF_2β, respectively in stably transfected Chinese hamster ovary cells^[2].

Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior^[3].

4707.26

C₂₀6H_338N62O64

171543-83-2

Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.