Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) is a neuropeptide and a potent endogenousCRFRagonist withK_is of 13 nM, 1.5 nM, and 0.97 nM forhuman CRF₁,rat CRF_2αandmouse CRF_2β, respectively^[1][2].

Ki: 13 nM (Human CRF₁), 1.5 nM (Rat CRF_2α), and 0.97 nM (Mouse CRF_2β)^[1]

Urocortin, rat induces cyclic AMP (cAMP) generation with EC₅₀of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF₁, rat CRF_2αand mouse CRF_2β, respectively in stably transfected Chinese hamster ovary cells^[2].

Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior^[3].

4821.28

C₂₀8H_339N62F3O66

DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.