JNJ-26070109 is a high-affinity, competitive, orally bioactive, and selectivecholecystokinin 2(CCK2) receptor antagonist with good pharmacokinetic properties, withpK_is of 8.49, 7.99, and 7.70 for human, rat, and dog CCK2 receptors, respectively. The dual function of CCK2 receptors in regulating gastric acid secretion and growth of the gastrointestinal mucosa make this an attractive and novel target for the treatment of gastroesophageal reflux disease^[1].

pK_i: 8.49 (human CCK2), 7.99 (rat CCK2), 7.70 (dog CCK2)^[1]

547.37

C₂₃H₁₇BrF₂N₄O₃S

844645-08-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.