CAS NO: | 1228650-83-6 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | CCR2 antagonist5 is a selective, orally activehCCR2inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM).CCR2 antagonist5 displays a Kiof 9.6 μM for mCCR2 binding.CCR2 antagonist5 can be used in the research of inflammatory disease[1]. | |||||||||||||||||||||||||
IC50& Target[1] |
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体内研究 (In Vivo) | CCR2 antagonist 5 (compound 8d) dose-dependently inhibits the influx of leukocytes, monocytes/macrophages and T-lymphocytes into the peritoneal cavity with an ED50of 3 mg/kg p.o. bid in a thioglycollate-induced peritonitis (TG) model[1].
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分子量 | 482.52 | |||||||||||||||||||||||||
Formula | C22H25F3N4O3S | |||||||||||||||||||||||||
CAS 号 | 1228650-83-6 | |||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |