SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC₅₀=520 nM), precursor of SB-423562 (IC₅₀=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation^[1].

IC50: 520 nM (Calcium-sensing receptor)^[1]

SB-423557 (oral administration; 10, 30 or 100 μM/kg; once daily; 12 weeks) elicits transient increases in plasma concentrations of PTH, resulting in increased bone mass and strength in both vertebrae and long bones compared to that of OVX controls^[1].

464.60

C₂₈H₃₆N₂O₄

351490-26-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.