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SCH 336
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SCH 336图片
CAS NO:447459-51-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
SCH-225336
产品介绍
SCH 336 是一种有效的、选择性的、反向的和具有口服活性的CB2激动剂。SCH 336 抑制 BaF3/CB2 细胞迁移。SCH 336 显着抑制体内白细胞的迁移。SCH 336 可阻断卵白蛋白诱导的小鼠肺嗜酸性粒细胞增多。
生物活性

SCH 336 is a potent, selective, inverse and orally activeCB2agonist. SCH 336 inhibits BaF3/CB2 migration. SCH 336 significantly inhibits the migration of leukocytes in vivo. SCH 336 blocks ovalbumin-induced lung eosinophilia in mice[1].

IC50& Target[1]

hCB2-R

 

体外研究
(In Vitro)

SCH 336 (Sch.336) (0-10 μM) competes with [3H]CP55,940 for binding to human CB2 on Sf9 cell membranes with Kiof 1.8 nM, and decreases GTPγS binding on human CB2-containing membranes with an EC50of 2 nM, decreases potency on CB1-containing membranes with EC50of 200 nM[1].
SCH 336 inhibits BaF3/CB2 migration to 100 nM 2-AG with an IC50of 34 nM[1].

体内研究
(In Vivo)

SCH 336 (0.02, 0.2, 2.0 mg/kg; i.p.) significantly inhibits the migration of leukocytes[1].

Animal Model:Female B6D2/F1 mice (HU210)[1]
Dosage:0.02, 0.2, 2.0 mg/kg
Administration:I.p.
Result:Significantly inhibited the migration of leukocytes into the CCL2-soaked gel foam sponge.
分子量

539.64

Formula

C23H25NO8S3

CAS 号

447459-51-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.