CB2 receptor agonist 2

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CAS NO:	1314230-75-5
包装:	1mg
市场价:	2200元

产品介绍

CB2 receptor agonist 2 是CB2受体的有效和选择性激动剂。对CB2的K_i为 8.5 nM。CB2 receptor agonist 2 对CB2具有高亲和力和选择性。

生物活性

CB2receptor agonist 2 is a potent and selective agonist for theCB2(cannabinoid type 2) receptor with aK_iof 8.5 nM.CB2receptor agonist 2 has high affinity and selectivity forCB2^[1].

IC₅₀& Target^[1]

CB2

8.5 nM (Ki)

体外研究
(In Vitro)

CB2 receptor agonist 2 (compound 4g) (1 μM; 72 hours) has very low or no cytotoxicity to Hep-G2 cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	Hep-G2 (Human hepatoblastoma) cells
Concentration:	1 μM
Incubation Time:	72 hours
Result:	Exhibited very low or no cytotoxicity to Hep-G2 cells.

体内研究
(In Vivo)

CB2 receptor agonist 2 (compound 4g) (1 and 3 mg/kg; 1 hour) is very potent (with maximal effect being reached already at the 1 mg/kg dose) and has antihyperalgesic effects, efficacious also on the first phase of the nocifensive response and strongly reduced by AM630 (CB2-selective antagonist/inverse agonist)^[1].

Animal Model:	Formalin injection induces a biphasic stereotypical nocifensive behavior in mice^[1]
Dosage:	Formalin (1.25% in saline, 30 μL), 1 and 3 mg/kg CB2 receptor agonist 2, 1 mg/kg AM630, monitor every 5 minutes for 1 hour
Administration:	Injection in the dorsal surface of one side of the hindpaw (Formalin), i.p. (CB2 receptor agonist, AM630)
Result:	Elicited antihyperalgesic effects and potent (with maximal effect being reached already at the 1 mg/kg dose) and efficacious, strongly reduced by AM630.

分子量

488.62

Formula

C₃₀H₃₆N₂O₄

CAS 号

1314230-75-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.