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CB1/2 agonist 2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CB1/2 agonist 2图片
CAS NO:2772379-97-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CB1/2 agonist 2 (compound 23) 是一种有效的非选择性大麻素 (cannabinoid) 配体,其Ki分别为 3.5 nM 和 1.2 nM。CB1/2 agonist 2 可以作为CB1的完全激动剂和CB2竞争性反向激动剂。CB1/2 agonist 2 具有抗伤害活性。
生物活性

CB1/2 agonist 2 (compound 23) is a potent non-selectivecannabinoidligand, withKivalues of 3.5 and 1.2 nM, respectively. CB1/2 agonist 2 can behave as a fullCB1agonist andCB2competitive inverse agonist. CB1/2 agonist 2 shows antinociceptive activity[1].

IC50& Target

hCB2-R

1.2 nM (Ki)

hCB1-R

3.5 nM (Ki)

体外研究
(In Vitro)

CB1/2 agonist 2 (compound 23) (1 μM, 24-72 h) exhibits a very low cytotoxic potential in Hep-G2 cells[1].
CB1/2 agonist 2 (0-10 μM) shows a slight but significant inhibition of [35S]GTPγS binding to hCB2-CHO cell membranes, with a mean EC50of 397.90 nM and a mean Emaxvalue of -17.81%[1].

Cell Cytotoxicity Assay[1]

Cell Line:Human hepatoblastoma (Hep-G2) cells
Concentration:1 μM
Incubation Time:24, 48 or 72 h
Result:Exhibited a very low cytotoxic potential, as Hep-G2 cell viability was comparable to controls after 24-72 h of treatment.
体内研究
(In Vivo)

CB1/2 agonist 2 (compound 23) (0-6 mg/kg, IP, once) significantly reduces the late phase of formalin-induced nocifensive behaviour at 6 mg/kg[1].

Animal Model:Male CD-1 outbred mice (40-45 g)[1]
Dosage:0, 1, 3, and 6 mg/kg
Administration:IP, once, 10 min before the formalin or saline injection
Result:Significantly reduced the late phase of formalin-induced nocifensive behaviour at the highest dose (6 mg/kg, i.p.), whereas no effect was produced by doses of 1 and 3 mg/kg.
分子量

417.62

Formula

C26H43NO3

CAS 号

2772379-97-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.