PM226

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PM226

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1949726-13-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PM226 是一种选择性的大麻素CB2R激动剂 (K_i(CB2R)=13 nM；EC₅₀(CB2R)=39 nM；K_i(CB1R) >40 μM)，在体内外均具有神经保护特性。

生物活性

PM226 is a selectivecannabinoid CB2Ragonist (K_i(CB2R)=13 nM;EC₅₀(CB2R)=39 nM; K_i(CB1R) >40 μM;) with neuroprotective properties in vitro and vivo^[1].

IC₅₀& Target^[1]

CB2

13 nM (Ki)

CB2

39 nM (EC₅₀)

体外研究
(In Vitro)

PM226 binds selectively to CB2 receptor with an affinity in the nanomolar range (K_i=12.8±2.4 nM). PM226 has negligible affinity for the CB1 receptor (K_i>40000 nM) and no activity at the GPR55. PM226 was also evaluated in GTPγS binding assays specific to the CB2 receptor showing agonist activity (EC₅₀=38.67±6.70 nM)^[2].

体内研究
(In Vivo)

PM226 (0.1, 1 and 10 mg/kg; administered i.p.) administration decreases the volume of the striatal lesion caused by Malonate^[2].

Animal Model:	Malonate-lesioned adult (12 week old; 350-400 g) male Wistar rats^[2]
Dosage:	0.1, 1 and 10 mg/kg
Administration:	Administered i.p.
Result:	Reduced the volume of edema observed in Malonate-lesioned rats at the dose of 1 mg/kg.

分子量

357.49

Formula

C₂₂H₃₁NO₃

CAS 号

1949726-13-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.