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Verubecestat TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Verubecestat TFA图片
CAS NO:2095432-65-6
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)523.43
FormulaC19H18F5N5O5
CAS No.2095432-65-6 (TFA)
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 81 mg/mL (154.74 mM)
Water: <1 mg/mL
Ethanol: 2 mg/mL (3.82 mM)
SMILESO=C(NC1=CC=C(F)C([C@@](C2)(C)N=C(N)N(C)S2(=O)=O)=C1)C3=NC=C(F)C=C3.O=C(O)C(F)(F)F
Synonyms MK-8931 TFA; SCH 900931; MK 8931 trifluoroactice acid; SCH-900931; MK8931; MK-8931-009; SCH900931 TFA
实验参考方法
In Vitro

In vitro activity: Verubecestat(MK-8931) effectively reduces Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM


Kinase Assay: Verubecestat (MK-8931) is a beta-secretase 1/BACE1 inhibitor under investigation for the treatment of Alzheimer's Disease.

In VivoVerubecestat(MK-8931) dramatically lowers CSF and cortex Aβ40 in both rats and cynomolgus monkeys following a single oral dose. Due to the 20 h half-life of MK-8931 it is ideal for once-a-day dosing.
Animal modelRats and cynomolgus monkeys
Formulation & DosageNA
ReferencesBioDrugs. 2016 Jun;30(3):173-94; Transl Neurodegener. 2016 Jul 14;5:13.