CAS NO: | 287937-12-6 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Virodhamine is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist ofCB1receptor and an agonist ofCB2receptor. Virodhamine induces megakaryocytic differentiation by triggeringMAPKsignaling andROSproduction. Virodhamine can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases[1][2]. | ||||||||||||||||
体外研究 (In Vitro) | Virodhamine (50 nM; 72 h) increases adherence, membrane expansion and the size of nucleus[1].Virodhamine (10-40 μM; 72 h) increases the expression level of CD61 and TRPV1[1].Virodhamine (72 h) inhibits the cell proliferation of megakaryocyte cells and significantly increases the portion of high ploidy cells as compared to control[1].Virodhamine significantly increases the protein expression level of CB2 receptorn, ROS production and NAPDH oxidase NOX4 expression in megakaryocytic cells[1]. RT-PCR[1]
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体内研究 (In Vivo) | Virodhamine (1-10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in vivo[2].
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分子量 | 347.53 | ||||||||||||||||
性状 | Viscous liquid | ||||||||||||||||
Formula | C22H37NO2 | ||||||||||||||||
CAS 号 | 287937-12-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 100 mg/mL(287.74 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |