(Sar1)-Angiotensin II

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CAS NO:

51833-69-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

(Sar1)-Angiotensin II，一种血管紧张素 II (Angiotensin II) 的类似物，是血管紧张素AT1受体的特异性激动剂。(Sar1)-Angiotensin II 以 2.7 nM 的K_d值结合到富含脑膜的颗粒上。(Sar1)-Angiotensin II 可以刺激雏鸡心肌细胞中的蛋白质合成和细胞生长。

生物活性

(Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist ofangiotensinAT1 receptor. (Sar1)-Angiotensin II binds to brain membrane-rich particles, with aK_dof 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes^[1]^[2]^[3].

体外研究
(In Vitro)

(Sar1)-Angiotensin II (1 μM/day; 9 d) increases the total protein content in embryonic chick myocytes by 18.5, 26.2, and 22.2% at 5, 7, and 9 days, respectively^[2].
(Sar1)-Angiotensin II binds to brain membrane-rich particles in cynomolgus monkey brain, with a K_dof 2.7 nM^[3].

分子量

1002.17

Formula

C₄₉H₇₁N₁₃O₁₀

CAS 号

51833-69-3

Sequence Shortening

{Sar}-RVYIHPF

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.