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1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone图片
CAS NO:120693-53-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone,一种喹诺酮类生物碱,是二酰基甘油酰基转移酶抑制剂和血管紧张素 II 受体阻断剂,IC50值分别为 20.1 μM 和 34.1 μM。1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone 显示出有效的抗幽门螺杆菌活性,MIC 值为 10 μg/mL。
生物活性

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, aquinolonealkaloid, is adiacylglycerolacyltransferaseinhibitor andangiotensin II receptorblocker, withIC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pyloriactivity with the MIC of 10 μg/mL[1][2][3].

IC50& Target

IC50: 20.1 μM (diacylglycerol acyltransferase)[3], 34.1 μM (angiotensin II receptor)[2]

体外研究
(In Vitro)

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows anti-Helicobacter pylori activity, with the MIC of 10 μg/mL, and has no effect on Helicobacter pylori urease activity at the concentration of 300 μg/mL[1].
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-500 μM) shows a dose-dependent diacylglycerol acyltransferase (DGAT) inhibition, with an IC50of 20.1 μM[3].
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-20 μM) inhibits leukotriene biosynthesis in human polymorphonuclear granulocytes, with an IC50of 10.1 μM[4].

分子量

337.50

Formula

C23H31NO

CAS 号

120693-53-0

结构分类
  • Alkaloids
  • Quinoline Alkaloids
来源
  • Plants
  • Rutaceae
  • Evodia rutaecarpa(Juss.) Benth.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.