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VU 0238429
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
VU 0238429图片
CAS NO:1160247-92-6
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
VU 0238429 是毒蕈碱乙酰胆碱受体亚型 5（mAChR5 或 M5）的正变构调节剂，EC50 为 1.16 μM。
Cas No.1160247-92-6
化学名1-(4-methoxybenzyl)-5-(trifluoromethoxy)indoline-2,3-dione
Canonical SMILESFC(F)(OC1=CC=C(C(C2=O)=C1)N(C2=O)CC(C=C3)=CC=C3OC)F
分子式C17H12F3NO4
分子量351.28
溶解度<35.13mg/ml in DMSO
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM.

VU 0238429 is positive allosteric modulator of mAChR5 (M5), with an EC50 of 1.16 μM, >30-fold selectivity versus M1 and M3, with no M2 or M4 potentiator activity[1].

References:
[1]. Bridges TM, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.