Iloperidone hydrochloride (HP 873 hydrochloride) is aD₂/5-HT₂receptor antagonist. Iloperidone hydrochloride is an atypical antipsychotic for the schizophrenia symptoms^[1][2].

Iloperidone hydrochloride displays higher affinity for the dopamine D₃receptor (K_i=7.1 nM) than for the dopamine D₄receptor (K_i=25 nM). Iloperidone displays high affinity for the 5-HT₆and 5-HT₇receptors (K_i=42.7 and 21.6 nM, respectively), and is found to have higher affinity for the 5-HT_2A(Ki=5.6 nM) than for the 5-HT_2Creceptor (K_i=42.8 nM)^[1].

Iloperidone hydrochloride is eliminated slowly, with a mean t_1/2of 13.5 to 14.0 hours. Coadministration with food did not significantly affect AUC, t_max, or C_max. These results indicate that the rate of iloperidone's absorption is decreased, but the overall bioavailability is unchanged, when the drug is taken with food. Orthostatic hypotension, dizziness, and somnolence were the most commonly reported adverse events^[2].

462.94

C₂₄H₂₈ClFN₂O₄

1299470-39-5

盐酸伊潘立酮；盐酸哌啶酮

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