BMY 7378

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BMY 7378

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

21102-95-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

BMY 7378 是 α_1D肾上腺素受体(α_1D-AR)的选择性拮抗剂。BMY 7378 与表达克隆大鼠 α_1D-AR 的膜结合的亲和力 (K_i=2 nM) 高于与克隆大鼠 α_1A-AR (K_i=800 nM) 或仓鼠 α_1B-AR (K_i=600 nM) 结合的亲和力 >100 倍。BMY 7378 是一种5-HT_1A受体部分激动剂。

生物活性

BMY 7378 is a selective antagonist of α_1D-adrenoceptor (α_1D-AR). BMY 7378 binds to membranes expressing the cloned rat α_1D-AR with a >100-fold higher affinity (K_i=2 nM) than binding to either the cloned rat α_1A-AR (K_i=800 nM) or the hamster α_1B-AR (K_i=600 nM). BMY 7378 is a5-HT_1Areceptor partial agonist^[1]^[2].

IC₅₀& Target^[1]

rat α_1A-adrenergic receptor

800 nM (Ki)

hamster alpha_1B-adrenergic receptor

600 nM (Ki)

rat alpha_1D-adrenergic receptor

2 nM (Ki)

5-HT_1AReceptor

体外研究
(In Vitro)

BMY 7378 is selective for the alpha 1D-adrenoceptor subtype (pK_i: hamster alpha 1b-adrenoceptor 6.2, human alpha 1b-adrenoceptor 7.2; bovine alpha 1c-adrenoceptor 6.1, human alpha 1c-adrenoceptor 6.6; rat alpha 1d-adrenoceptor 8.2, human alpha 1d-adrenoceptor 9.4) and has high affinity (pA₂, 8.9) for rat aorta alpha 1-adrenoceptor^[2].

分子量

458.42

Formula

C₂₂H₃₃Cl₂N₃O₃

CAS 号

21102-95-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.