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Renzapride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Renzapride图片
CAS NO:112727-80-7
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
BRL 24924
产品介绍
Renzapride (BRL 24924)，是一种取代苯甲酰胺，是5-HT4受体激动剂，也是5HT2b和5HT3受体拮抗剂。Renzapride (BRL 24924) 可以用于便秘型肠易激综合征 (C-IBS) 的研究。
生物活性

Renzapride (BRL 24924), a substituted benzamide, is a full5-HT4receptoragonist with aKivalue of 115 nM. Renzapride (BRL 24924) is also a5HT2band5HT3 receptorantagonist[1]. Renzapride could be used for constipation predominant irritable bowel syndrome (C-IBS) study[2].

IC50& Target[1]

5-HT4Receptor

115 nM (Ki)

体外研究
(In Vitro)

Renzapride replaces specific binding of [H3] GR 113808 (a selective 5-HT receptor antagonist) to cloned human 5-HT4receptors with a Kivalue of 115 nM[3].

体内研究
(In Vivo)

Renzapride (BRL 24924) (100 μg i.v.) results in a partial reverse of both the delayed solid and liquid meals emptying[2].
Renzapride (BRL 24924) (0.5-1 mg/kg) significantly increases the rate of emptying of a51Cr-labeled liquid meal from the murine stomach[4].

Animal Model:Dog (simulating gastroparesis)[2]
Dosage:100 μg/kg
Administration:i.v.
Result:Results in a partial reverse of both the delayed solid and liquid meals emptying.
Animal Model:Mice (30-45g)[2]
Dosage:0.5-1 mg/kg
Administration:p.o.
Result:Significantly increase the rate of emptying of a51Cr-labeled liquid meal from the murine stomach.
Clinical Trial
分子量

323.82

性状

Solid

Formula

C16H22ClN3O2

CAS 号

112727-80-7

中文名称

伦扎必利

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month