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LP 12 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LP 12 hydrochloride图片
CAS NO:1185136-22-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
LP 12 hydrochloride (compound 21) 是一种有效的选择性5-HT7受体激动剂,Ki为 0.13 nM。LP 12 hydrochloride 对 5-HT7 的选择性优于 D2、5-HT1A 和 5-HT2A 受体 (Ki值分别为 224 nM、60.9 nM 和 >1000 nM)。
生物活性

LP 12 hydrochloride (compound 21) is a potent and selective5-HT7 receptoragonist with aKiof 0.13 nM. LP 12 hydrochloride displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Kivalues are 224 nM, 60.9 nM and >1000 nM, respectively)[1][2].

IC50& Target[1]

5-HT7Receptor

0.13 nM (IC50)

5-HT1AReceptor

60.9 nM (IC50)

5-HT2AReceptor

1464 nM (IC50)

体外研究
(In Vitro)

LP 12 hydrochloride (0.13 nM; spermatozoa) increases the percentage of hyperactivated spermatozoa. LP 12 hydrochloride do not affect straight-line velocity (VSL), curvilinear velocity (VCL), average-path velocity (VAP), linearity (LIN), straightness (STR), wobbler coefficient (WOB), amplitude of lateral head displacement (ALH), and beat-cross frequency (BCF)[2].

分子量

518.13

Formula

C32H40ClN3O

CAS 号

1185136-22-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.