ST1936 oxalate is a selective, nanomolar affinity5-HT₆receptoragonist withK_ivalues of 13 nM, 168 nM and 245 nM for human5-HT₆, 5-HT₇and 5-HT_2Breceptors, respectively. ST1936 oxalate also shows moderate affinity (K_iof 300 nM) for human and ratα2adrenergic receptor^[1].

ST1936 oxalate appears to be relatively selective for 5-HT₆receptors, although it has shown affinity also for 5-HT_2B, 5-HT_1A, 5-HT₇receptor and α-adrenergic receptors when tested in a broad crossreactivity panel that comprised G-protein-coupled receptors, ion channel binding sites, enzymes, and transporters^[1].
ST1936 oxalate behaves as a full 5-HT₆agonist on cloned cells and is able to increase Ca²⁺concentration, phosphorylation of Fyn kinase, and regulate the activation of ERK1/2 that is a downstream target of Fyn kinase^[2].
ST1936 oxalate reduces the frequency of spontaneous excitatory postsynaptic currents, with an IC₅₀of 1.3 μM^[3].

ST1936 (5, 10, 20 mg/kg; i.p.) oxalate increases in a dose dependent manner extracellular dopamine (DA) and NA levels in the prefrontal cortex (PFCX)^[2].
ST1936 (5, 10, 20 mg/kg; i.p.) oxalate increases extracellular DA and NA levels in the nucleus accumbens (NAc) core. Doses of 10 mg/kg increases dialysate DA (peak: 179%) while higher dose increases both DA and NA dialysates (201% and 231%, respectively). Doses of 5 mg/kg does not produce any effect^[2].

326.78

C₁₅H₁₉ClN₂O₄

1782228-83-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.