LY266097 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

172895-39-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

LY266097 hydrochloride 是一种选择性的5-HT2B受体拮抗剂，对5-HT2A、5-HT2B、5-HT2C的pK_i分别为 7.7、9.8 和 7.6。5-HT2B 受体阻断有助于抑郁症的研究。

生物活性

LY266097 hydrochloride is a selective5-HT2Breceptor antagonist withpK_is of 7.7, 9.8, and 7.6 for5-HT2A,5-HT2B,5-HT2C, respectively. 5-HT2B receptor blockade contributes to the research in depression^[1].

IC₅₀& Target^[1]

5-HT_2BReceptor

9.8 (pKi)

5-HT_2AReceptor

7.7 (pKi)

5-HT_2CReceptor

7.6 (pKi)

体外研究
(In Vitro)

LY266097 is a highly selective 5-HT2B receptor antagonist with a pK_iof 9.7 for the human cloned 5-HT2B receptor and a 100-fold greater selectivity over human 5-HT2C and 5-HT2A sites^[2].

体内研究
(In Vivo)

LY266097 (0.6 mg/kg for 2-day administration) rescues Escitalopram-induced decrease in dopamine (DA)^[1].
The administration of LY266097 alone or its addition on the last 3 days of a 14-day Escitalopram regimen increases pyramidal neuron firing and burst activity^[1].

Animal Model:	Male Sprague-Dawley rats weighing 250-350 g^[1]
Dosage:	0.6 mg/kg
Administration:	Administered i.p. alone or concomitantly with Escitalopram (2 mg/kg) for 2 days
Result:	Short-term administration (0.6 mg/kg/day for 2 days; i.p.) alone had no effect on these parameters, its co-administration counteracted the inhibitory effect of escitalopram on the firing activity of DA neurons, resulting in a recovery to control level.

分子量

407.33

Formula

C₂₁H₂₄Cl₂N₂O₂

CAS 号

172895-39-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.