CAS NO: | 200940-23-4 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | SB 243213 hydrochloride is an orally active, selective and high-affinity5-HT2Creceptorantagonist with apKiof 9.37 and apKbof 9.8 for human 5-HT2Creceptor. SB 243213 hydrochloride shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 hydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders[1]. | ||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | SB 243213 hydrochloride shows little affinity (pKi<6) for cloned human 5-HT1A, 5-HT1B, 5-HT1E, 5- HT1Fand 5-HT7receptors. It shows weak affinity (pKi<6.5) for the cloned human 5-HT1Dand D3 receptors and moderate affinity (pKi=6.7) for the cloned human D2 receptor[1]. | ||||||||||
体内研究 (In Vivo) | SB 243213 hydrochloride (0.1-10 mg/kg, p.o. 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box[1].
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分子量 | 464.87 | ||||||||||
Formula | C22H20ClF3N4O2 | ||||||||||
CAS 号 | 200940-23-4 | ||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |