您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > TC-O 9311
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
TC-O 9311
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TC-O 9311图片
CAS NO:444932-31-4
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
TC-O 9311 是一种有效的孤儿 G 蛋白偶联受体 139 (GPR139) 激动剂，EC50 为 39 nM。
Cas No.444932-31-4
化学名(Z)-N'-((Z)-hydroxy(naphthalen-1-ylimino)methyl)-3,5-dimethoxybenzohydrazonic acid
Canonical SMILESCOC1=CC(OC)=CC(/C(O)=N/N/C(O)=N/C2=CC=CC3=CC=CC=C32)=C1
分子式C20H19N3O4
分子量365.38
溶解度14mg/mL in ethanol or in DMF, 11mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TC-O 9311 is an agonist of the orphan G protein-coupled receptor GPR139 (EC50 = 39 nM in a calcium mobilization assay).[1] It is selective for GPR139 over a panel of 90 additional targets. TC-O 9311 (1 μM) inhibits cell death induced by 1-methyl-4-phenylpyridinium (MPP+), but not 6-hydroxydopamine, in primary dopaminergic midbrain neurons.[2]

Reference:
[1]. Shi, F., Shen, J.K., Chen, D., et al. Discovery and SAR of a series of agonists at orphan G protein-coupled receptor 139. ACS Med. Chem. Lett. 2(4), 303-306 (2011).
[2]. Bayer Andersen, K., Leander Johansen, J., Hentzer, M., et al. Protection of primary dopaminergic midbrain neurons by GPR139 agonists supports different mechanisms of MPP+ and rotenone toxicity. Front. Cell. Neurosci. 10:164, (2016).