CAS NO: | 1596-64-1 |
包装 | 价格(元) |
500mg | 电议 |
1g | 电议 |
5g | 电议 |
Cas No. | 1596-64-1 |
别名 | L-组氨醇二盐酸盐,(S)-Histidinol |
化学名 | (βS)-amino-1H-imidazole-5-propanol, dihydrochloride |
Canonical SMILES | OC[C@@H](N)CC1=CNC=N1.Cl.Cl |
分子式 | C6H11N3O o 2HCl |
分子量 | 214.1 |
溶解度 | ≤5mg/ml in DMSO |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | L-Histidinol is an intermediate in the biosynthesis of the amino acid L-histidine. L-Histidine biosynthesis is a metabolic pathway present in bacteria, archaea, lower eukaryotes, as well as plants. L-histidine biosynthesis has been studied mainly in Escherichia coli and Salmonella typhimurium, revealing fundamental regulatory processes in bacteria. In vitro: Preliminary experiments were done to investigate the cytotoxic effect of L-histidinol on cultured EAC cells. Results showed that L-histidinol up to 4 mM had no cytotoxic effects on EAC cells. Doxorubicin alone showed concentration-dependent cytotoxic effects. L-Histidinol combination with doxorubicin led to significant potentiation of doxorubicin cytotoxicity to EAC cells compared to doxorubicin alone. The concentration that caused 50% growth inhibition in EAC cells after 24 h incubation was about 0.2 μg/ml, whereas it was 0.1 μg/ml when L-histidinol was added to culture medium [1]. In vivo: L-Histidinol at 250 mg/kg for five consecutive doses before doxorubicin single injection could enhance the antitumour activity of doxorubicin in EAC-bearing mice as demonstrated by a significant increase in average life span and cure rate of mice. In normal mice, L-histidinol, in the same dose regimen, could not alter the acute cardiotoxicity and lethality of doxorubicin [1]. Clinical trial: So far, no clinical study has been conducted. Reference: |