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4-(n-nonyl)Benzeneboronic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-(n-nonyl)Benzeneboronic Acid图片
CAS NO:256383-45-6
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
500mg电议
1g电议

产品介绍
4-(n-nonyl) Benzeneboronic Acid (compound 13) 是一种有效的 FAAH 和 MAGL 双重抑制剂,IC50 值分别为 9.1 nM 和 7.9 μM。
Cas No.256383-45-6
别名4-壬基苯硼酸
化学名B-(4-nonylphenyl)-boronic acid
Canonical SMILESCCCCCCCCCC1=CC=C(B(O)O)C=C1
分子式C15H25BO2
分子量248.2
溶解度≥ 11.75mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 9.1 nM

4-(n-nonyl) Benzeneboronic acid is a dual FAAH inhibitor.

Fatty acid amide hydrolase (FAAH), a membrane-bound enzyme of the endocannabinoid system, has been identified as a potential target for therapeutic agents in the treatment of various medical conditions, such as inflammation and pain. FAAH and monoglyceride lipase (MGL) have been reported to be the primary enzyme responsible for the hydrolysis of endocannabinoid N-arachidonoyl ethanolamide (AEA), which is a key lipid messenger in the brain and periphery.

In vitro: 4-(n-Nonyl) benzeneboronic acid was synthezed as a potent inhibitor of FAAH, with an IC50 of 9.1 nM. 4-(n-Nonyl) benzeneboronic acid was also found to be able to inhibit MAGL, which could hydrolyze 2-arachidonoyl glycerol, but at around 1000-fold higher concentration. Moreover, it was found that as the most potent para-substituted compound, 4-(n-Nonyl) benzeneboronic acid showed rather high pKa of 9.1. In addition, the molecular docking was utilized to gain insight on the FAAH binding mode of 4-(n-Nonyl) benzeneboronic acid and a putative binding mode was observed [1].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Minkkil, A. ,Saario, S.M.,Ksnnen, H., et al. Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. Journal of Medicinal Chemistry 51, 7057-7060 (2008).