CAS NO: | 155428-00-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Alniditan (Alnitidan) dihydrochloride is a potent5-HT1Band5-HT1Dreceptorsagonist, withIC50s of 1.7 nM and 1.3 nM forh5-HT1Bandh5-HT1Dreceptorsin HEK 293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects[1][2]. | ||||||||||||||||
IC50& Target[2] |
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体外研究 (In Vitro) | In vitro, Alniditan exhibits little vasoconstrictive effects on the rat basilar artery, although at a very high concentration 1 mM, Alniditan causes intensive constriction, most likely through a mechanism independent from 5-HT receptor activation[1]. | ||||||||||||||||
体内研究 (In Vivo) | The intraperitoneal administration of Alniditan ED50=9 μg/kg dose dependly reduces [125I]-BSA extravasation in the rat meninges when done 30 min before stimulation. Alniditan dose dependently attenuateds the neurogenic inflammation in vivo model of neurogenic inflammation[1]. | ||||||||||||||||
分子量 | 375.34 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H28Cl2N4O | ||||||||||||||||
CAS 号 | 155428-00-5 | ||||||||||||||||
中文名称 | 阿尼地坦二盐酸盐 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 62.5 mg/mL(166.52 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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