CAS NO: | 40796-97-2 |
包装 | 价格(元) |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Bemesetron (MDL 72222) is a selective5-HT3receptorantagonist with anIC50of 0.33 nM[1]. Neuroprotective effect[2]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Blockade of 5-HT3receptor with Bemesetron (MDL7222) reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Bemesetron (0.01, 0.1 and 1 μM, 15 hours) and Y25130 (0.05, 0.5 and 5 μM) concentration-dependently reduce the H2O2-induced decrease of MTT reduction showing 74.9±2.4 and 79.0 ±2.5% with 1 μM and 5 μM, respectively, which are maximal effects[2]. Cell Viability Assay[2]
Western Blot Analysis[2]
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体内研究 (In Vivo) | Bemesetron (0.1, 1 and 10 mg/kg; i.p.) is used in male adult albino mice. The lowest dose do not cause any significant change in catalepsy. However, Bemesetron (1 mg/kg) causes a significant reduction of catalepsy (from 90 min after Haloperidol), while 10 mg/kg significantly potentiates the phenomenon (from 60 min after Haloperidol). The maximum inhibition of catalepsy (about 75%) occurs at 120 min, and the maximum potentiation (about 4.5-times the control value) occurs at 60 min after Haloperidol[3].
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分子量 | 314.21 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C15H17Cl2NO2 | ||||||||||||||||
CAS 号 | 40796-97-2 | ||||||||||||||||
中文名称 | 贝美司琼 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 2 mg/mL(6.37 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |