CAS NO: | 483-14-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Rotundine is an antagonist ofdopamine D1,D2andD3 receptorswithIC50s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of5-HT1Awith anIC50of 370 nM. | ||||||||||||||||
IC50& Target |
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体内研究 (In Vivo) | It is reported that Rotundine (l-THP) possesses a blocking effect on dopamine D1and D2receptors and can inhibit physical dependence in morphine dependent mice and significantly reduce the development of the conditional place preference induced by morphine in mice. On day 1 and 7, there is no difference in locomotor counts between the Rotundine groups (6.25, 12.5, and 18.75 mg/kg) and saline group [F(3, 37)=1.360, P>0.05, F(3, 37)=0.348, P>0.05, respectively]. Locomotor counts are greatly increased in the oxycodone group compare with the saline group. Rotundine at doses of 6.25, 12.5, and 18.75 mg/kg antagonizes hyperactivity induced by oxycodone [F(4, 60)=15.76, P<0.01]. Rotundine (6.25, 12.5 mg/kg) does not affect the magnitude of sensitization, but there is a marked difference between oxycodone+oxycodone group and Rotundine (18.75 mg/kg)+oxycodone+oxycodone group, indicating that Rotundine (18.75 mg/kg) greatly inhibits the development of oxycodone sensitization [F(4, 62)=8.766, P<0.01][2]. | ||||||||||||||||
分子量 | 355.43 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H25NO4 | ||||||||||||||||
CAS 号 | 483-14-7 | ||||||||||||||||
中文名称 | 罗通定;罗痛定;颅通定;颅痛定;(-)-四氢帕马丁;(-)-延胡索乙素;L-四氢帕马丁;L-延胡索乙素 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 100 mg/mL(281.35 mM) H2O : 0.67 mg/mL(1.89 mM;Need ultrasonic) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |